MEDIA INQUIRIES
Oops! Something went wrong while submitting the form.
With the development of genetic technologies to precisely alter, or "perturb," cells comes the opportunity to understand cell-state transitions, which are fundamental to any biological process. But the huge number of ways we can perturb cells makes it challenging to test out these alterations in the lab.
That's why the Eric and Wendy Schmidt Center is developing novel active learning frameworks that can hone in on which perturbations can bring about desired cell state transitions — and provide other insights into how cells work.
Xiong, K., Zhang, R., & Ma, J.
(
2024
).
scGHOST: Identifying single-cell 3D genome subcompartments.
Nature Methods.
,
(
).
https://doi.org/10.1038/s41592-024-02230-9Shiragur, K., Zhang, J., & Uhler, C.
(
2023
).
Meek separators and their applications in targeted causal discovery.
Advances in Neural Information Processing Systems (NeurIPS 2023).
,
(
).
https://doi.org/10.48550/arXiv.2310.20075Braunger, J. M., Cammarata, L. V., Sornapudi, T. R., Uhler, C., & Shivashankar, G. V.
(
2023
).
Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging.
Aging Cell
,
23
(
3
).
https://doi.org/10.1111/acel.14056Chaung, K., Baharav, T. Z., Henderson, G., Zheludev, I. N., Wang, P. L., & Salzman, J.
(
2023
).
SPLASH: A statistical, reference-free genomic algorithm unifies biological discovery.
Cell
,
186
(
25
).
https://doi.org/10.1016/j.cell.2023.10.028
